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Education Resources

Hypopharyngeal Cancer

Hypopharyngeal cancer is a disease in which malignant (cancer) cells form in the tissues of the hypopharynx— the bottom part of the pharynx (throat).

The pharynx is a hollow tube about 5 inches long that leads from the oral and nasal cavities in the head to the esophagus (the tube that goes from the throat to the stomach) and larynx (voice box). The pharynx serves a purpose in both the respiratory and digestive processes.

Most hypopharyngeal cancers form in squamous cells, the thin, flat cells lining the inside of the hypopharynx.

The hypopharynx is divided into three regions: the posterior pharyngeal wall, the piriform sinuses, and the postcricoid region. Cancer may be found in 1 or more of these areas.

Pharynx location in the throat

Hypopharyngeal Cancer Risk Factors

A risk factor is anything that increases your risk of getting a disease. Risk factors of hypopharyngeal cancer may include:

  • Smoking and/or chewing tobacco
  • Frequent and/or heavy alcohol consumption
  • Poor nutrition
  • Human papillomavirus (HPV) infection
  • Genetic syndromes (inherited gene mutations)
  • Exposures to certain fumes and chemicals in the workplace
  • Gender (more common in men than women)
  • Age (people over 55 are at higher risk)
  • Race (more common among African Americans and caucasians)
  • Gastroesophageal reflux disease (GERD)
  • Having Plummer-Vinson syndrome (a disorder that involves iron deficiency and causes difficulty swallowing)

It’s important to remember that having a risk factor, or even several of them, does not mean that you will get hypopharyngeal cancer. Likewise, many people who do get the disease may have few or no known risk factors at all.

Signs and Symptoms of Hypopharyngeal Cancer

People with hypopharyngeal cancer may experience the following signs and symptoms. Keep in mind, however, that these can also be related to something other than cancer. See your doctor if you have:

  • A sore throat that does not go away
  • Ear pain
  • A lump in the neck
  • Pain or difficulty when swallowing
  • Constant, persistent coughing
  • A change in voice
  • Chronic bad breath
  • Difficulty breathing

Again, these could be symptomatic of a different condition. With that said, if any of these symptoms lasts for more than three weeks, it’s a good idea to schedule an appointment with your doctor to be checked. If it is cancer, early detection can give you better treatment results.